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Figure 4 SERCA2a Overexpression After Gene Transfer With rAAV1 Vector

After gene transfer with the cardiotropic viral vector, rAAV1, both protein expression levels (A) as well as mRNA levels (B) of SERCA2a were found to be significantly elevated when compared with SERCA2a tissue expression in the saline group. This confirms the ability of this viral vector to promote the persistent overexpression (2 months after gene transfer) of the calcium cycling protein, SERCA2a. Control = normal heart group; GAPDH = glyceraldehyde 3-phosphate dehydrogenase; HF = heart failure; other abbreviations as in Figure 1.