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Figure 3 LV Internal Systolic Diameters at 4 Months

Despite comparable diameters at baseline and at the time of gene transfer, the saline group showed evidence of progression of their LV internal systolic diameters at the term of the study. Conversely, animals that underwent rAAV1.SERCA2a gene transfer were documented with persistent, stable LV internal systolic diameters. This confirms a positive effect on LV remodeling of SERCA2a overexpression. Abbreviations as in Figure 1.