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Figure 1 Differences in Adjusted Peak LV Pressure Rate of Rise

Relative to the saline group, study animals that underwent gene transfer with recombinant adeno-associated virus type 1 (rAAV1) sarcoplasmic reticulum Ca²⁺ ATPase (SERCA2a) had: 1) comparable peak left ventricular pressure rate (dP/dt)max/P at the 2-month time point (state of compensated volume-overload heart failure); and 2) significant improvement in (dP/dt)max/P. This confirms a positive effect on left ventricular (LV) inotropy of SERCA2a overexpression.