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Figure 4 Heart Rate Reduction and Myocardial Ischemia

Relationship between the improvement in time to myocardial ischemia during bicycle exercise and the reduction in exercise heart rate achieved in stable angina patients after treatment with 2 doses of 3 different calcium channel blockers (amlodipine, diltiazem, and mibefradil). Reprinted with permission from van der Vring et al. (22). bpm = beats/min.