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Figure 2 Changes in Skin SNA and Skin Vascular Resistance In Response to Cocaine and Dex

Intranasal cocaine increased skin sympathetic nerve activity (SNA), which was accompanied by a parallel increase in skin vascular resistance. Dexmedetomidine (Dex) reversed effects of cocaine on SNA and skin vascular resistance, beginning at the dose of 0.1 µg/kg/min. Data are mean ± SE. *p < 0.05 versus baseline, p < 0.01 versus baseline, p < 0.05 versus saline, p < 0.01 versus saline.