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Figure 1 Effects of CB₁ Antagonists on DOX-Induced Cardiac Dysfunction

Effect of doxorubicin (DOX) on left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), LV maximum first derivative of ventricular pressure with respect to time (+dP/dt), LV –dP/dt, heart rate, stroke work, ejection fraction, and cardiac output and tau (Weiss and Glantz) in mice. Mice were pretreated either with vehicle, rimonabant, or AM281, and treated with either vehicle or DOX, as indicated in the Methods section. Hemodynamic parameters were measured 5 days after DOX administration. Results are mean ± standard error of the mean of 7 to 13 experiments in each group. *p < 0.05 versus vehicle; #p < 0.05 versus DOX. CB₁ = cannabinoid-1.