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Figure 2 Echocardiographic Analysis on Cardiomyopathic Hamsters

Normal F1B (orange bars, n = 10), rAAV/LacZ (blue bars, n = 12), and rAAV/ASKN(KR) (red bars, n = 19) hamsters were analyzed with echocardiography before, 6 weeks, and 14 weeks after gene transfer (GT). (A) Representative M-mode echocardiographic tracings 14 weeks after GT. (B) Left ventricular fractional shortening (LVFS), (C) LV ejection fraction (LVEF), (D) LV end-diastolic dimension (LVEDD), (E) LV end-systolic dimension (LVESD), (F) diastolic wall thickness of interventricular septum (IVSd), (G) diastolic wall thickness of LV posterior wall (LVPWT), and (H) LVEDD/LVPWT (index of LV diastolic wall stress). Pre-, 6 weeks, and 14 weeks represent before, 6, and 14 weeks after gene transfer, respectively. *p < 0.05 versus rAAV/LacZ at the corresponding time point. p < 0.05 versus normal hamsters. Abbreviations as in Figure 1.