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Figure 4 Statin Treatment Reduces AF and NADPH-Oxidase Activity in RacET Mice

(A) Incidence of AF and (B) representative electrocardiography recording in RacET10 and RacET10 + statin, n = 10 to 15. (C) Representative Sirius red staining (10- and 100-fold magnification) and (D) quantification of interstitial fibrosis in the LA, n = 10 to 15, p = NS. (E) Atrial NADPH oxidase activity at baseline and after exposure to Ang, 1 µmol/l, 10 min, in RacET10 and RacET10 + statin; n = 8, *p < 0.05 versus untreated RacET10 and #p < 0.05 versus RacET10 + Ang. Abbreviations as in Figure 1.