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Figure 2 RacET Mice Exhibit Increased Atrial Fibrosis and NADPH-Oxidase Activity

(A) Representative Sirius red staining (10- and 100-fold magnification) in the left atrium (LA) and the LV in WT, RacET16, and TAC16. (B) Quantification of interstitial fibrosis in the LA and (C) the LV. n = 10, *p < 0.05 versus WT, #p < 0.05 versus TAC16. (D) Atrial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity at baseline and after exposure to angiotensin II (Ang), 1 µmol/l, 10 min, in WT, RacET16, and TAC16; n = 6, *p < 0.05 versus WT, #p < 0.05 versus TAC16. Abbreviations as in Figure 1.