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Figure 1 Pedigrees of the Families With Fabry Disease

Circles are women and squares are men. Filled symbols are affected patients (all with mutation). Symbols with an "N" indicate unaffected relatives without mutation. Dotted symbols are patients with mutation without apparent clinical manifestations. Dashed symbols are deceased patients. Question marks indicate unknown or not confirmed phenotype but possibly affected. Numbers are ages. Index patients are indicated by the thick arrows. AF = atrial fibrillation; AV = atrioventricular; ECG = electrocardiogram; echo = echocardiogram; HCM = hypertrophic cardiomyopathy; ICD = implantable cardioverter-defibrillator; LV = left ventricular; LVH = left ventricular hypertrophy; TX = transplant.