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Figure 3 AMD Composite Genomic Risk

Relative risk plotted as a function of the genetic load of the 5 variants that influence risk of age-related macular degeneration (AMD). Two variants are in the CFH gene on chromosome 1: Y402H and rs1410996. Another common variant (A69S) is in the hypothetical gene LOC387715 on chromosome 10. Two relatively rare variants are observed in the C2 and BF genes on chromosome 6. There was no evidence for interaction between any of the variants, suggesting an independent mode of action. Reprinted with permission from Maller et al. (18).