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Figure 1 Schematic of Genetic Linkage and Recombination

(A) Two homologous chromosomes: blue (paternal) and orange (maternal). Three genes with separate alleles and linkage disequilibrium "bins" noted (A,a; B,b; C,c; bins 1 to 4). (B) Crossing over during meiosis. (C) Two alleles and their linked bins (C,c; bins 3 and 4) have switched locations via recombination. Four additional alleles and their associated bins (A,a; B,b; bins 1 and 2) have not switched and are considered linked. (D) Recombined haploid chromosomes segregate separately during meiosis as gametes before fertilization. (E) Sample recombination frequencies between genes demonstrating higher rates of recombination for genes further apart.