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Figure 4 Steady-State and 24 h Postdose Inhibition of Platelet Aggregation by Clopidogrel and AZD6140

Mean percentage inhibition of platelet aggregation both after 4 weeks of study medication (clopidogrel-naïve patients) and 24 h after discontinuation of study medication derived from (A) maximum aggregation response and (B) final aggregation response at 6 min after addition of adenosine diphosphate 20 µmol/l, before and after the next dose of either clopidogrel 75 mg (n = 10), AZD6140 90 mg (n = 15), or AZD6140 180 mg (n = 10). Error bars show standard deviation and points are nudged on the X axis only to reveal error bars. *p < 0.05 for AZD6140 versus clopidogrel; p < 0.05 for clopidogrel predose versus 2 h postdose.