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Figure 3 Individual Responses to Clopidogrel and AZD6140

Individual area-under-the-curve data for inhibition of platelet aggregation derived from final aggregation response at 6 min after addition of ADP 20 µmol/l, for clopidogrel-naïve patients (A) after the first dose of either clopidogrel 300 mg, AZD6140 90 mg, AZD6140 180 mg, or AZD6140 270 mg and (B) after 4 weeks of treatment and after next dose of either clopidogrel 75 mg, AZD6140 90 mg, or AZD6140 180 mg. Data are for the first 8 h of treatment but are representative of the smaller numbers for whom data were available for the full 12 h. The lines indicate mean values. *p < 0.05 for AZD6140 versus clopidogrel. ADP = adenosine diphosphate; IPA = inhibition of platelet aggregation; other abbreviations as in Figure 1.