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Figure 4 Major Bleeding With Concurrent Use of GP IIb/IIIa Antagonists and Pretreatment With Clopidogrel

Major bleeding in relation to concurrent use of glycoprotein (GP) IIb/IIIa antagonists and clopidogrel pretreatment at least 6 h before percutaneous coronary intervention (PCI). Major bleeding was significantly reduced with fondaparinux (yellow) compared with enoxaparin (red) with or without concurrent use of these antiplatelet agents. GP IIb/IIIa (+) = GP IIb/IIIa inhibitor used before/during PCI; GP IIb/IIIa (–) = GP IIb/IIIa inhibitor not used before/during PCI; clopidogrel (+) = clopidogrel given at least 6 h before PCI; clopidogrel (–) = clopidogrel not given at least 6 h before PCI. CI = confidence interval; HR = hazard ratio.