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Figure 4 NADPH Oxidase-Dependent O2
– Production Detected by Lucigenin Chemiluminescence
(A) Nicotinamide adenine dinucleotide 3-phosphate (NADPH)-dependent superoxide production is increased in all failing hearts compared with control samples. The increase is more striking in MIC. *p < 0.05 versus NF; 
p < 0.001 versus NF; 
p < 0.001 versus DCM and IHD. (B) Effect of specific inhibitors of enzymatic reactive oxygen species production or of the superoxide scavenger Tiron. *p < 0.05 versus baseline; p < 0.01 versus baseline. DPI = diphenyleneiodonium; MLU = mean light units; other abbreviations as in Figure 2.