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Figure 1 GDF-15 Levels in 455 Patients With Chronic Heart Failure Stratified According to NYHA Functional Class or NT-proBNP Levels at Study Entry

Patients were stratified according to New York Heart Association (NYHA) functional class (A) or NT-proBNP quartiles (B). The GDF-15 levels are presented as box (25th percentile, median, 75th percentile) and whisker (10th and 90th percentiles) plots. Patient numbers are indicated. The NT-proBNP levels in the first quartile ranged from 20 to 305 ng/l, in the second quartile from 306 to 800 ng/l, in the third quartile from 801 to 2,307 ng/l, and in the fourth quartile from 2,308 to 88,300 ng/l. p < 0.001 by Kruskal-Wallis test in both panels. GDF-15 = growth differentiation factor 15; NT-proBNP = amino-terminal pro–B-type natriuretic peptide.