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Figure 1 LV Remodeling in Age-Matched Sham and ACF Rats

Left ventricular (LV) remodeling in aortocaval fistula (ACF) (open circles) at 12 h; 2 and 5 days; and 4, 8, and 15 weeks compared with age-matched shams (closed circles). Left ventricular end-diastolic dimension (LVEDD) (A), LVEDD/wall thickness (B), isolated cardiomyocyte length (C), left ventricular end-diastolic (LVED) wall thickness (D), and LV wet weight (E). Alternating black and white boxes each represent one 24-h period. Data are presented as mean ± SEM, n values given in Tables 1 and 2 except: 4-week sham LVEDD, LVEDD/wall thickness, LVED wall thickness (n = 9); 4-week ACF echocardiographic parameters and LV wet weight (n = 9); 8-week sham echocardiographic parameters and LV wet weight (n = 8); 15-week sham LV wet weight (n = 12); and 15-week ACF LV wet weight (n = 9). *p < 0.008 (= 0.05/6) for sham versus ACF at each time of the 6 time points except for isolated cardiomyocyte length, where p < 0.01 (= 0.05/5) for each of the 5 time points. Analyses were based on ranks of all the variables in this figure.