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Figure 5 Plasma and Plaque MP Thrombin-Generating Activity
(A) Representative trace of thrombin generation by plasma and plaque microparticles (MPs) isolated from the same patient. (B) Peak thrombin generation by venous, arterial, and plaque microparticles (n = 18, 15, and 20, respectively). (C) Total thrombin generated (area under curve) for the same samples as in panel B. (D) Peak thrombin generated by 105 cell-derived microparticles. *p < 0.05 (analysis of variance followed by Bonferonni post-test; 3 comparisons in panels B and C; 10 in panel D). EC = endothelial cell–derived; PLT = platelet-derived; RBC = red blood cell–derived; SMC = smooth muscle cell–derived.