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Figure 7 Left Ventricle Myocyte TUNEL Staining After LPS In Vivo Inhibited by Pre-Treating Rats With Cyclosporin A

Terminal deoxy-nucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining in the left ventricle (mean + SE, n = 5) increased 24 h after in vivo intravenous injection (tail vein) of lipopolysaccharide (LPS) (1 mg/kg) compared with control (saline injection) (p < 0.05, 2-way analysis of variance). This was blocked by pre-treating rats with cyclosporin A (20 mg/kg/day subcutaneously for 3 days before LPS or saline injections), while cyclosporin A treatment alone had no effect.