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Figure 4 LPS- or Ang II-Induced TUNEL Staining in Cardiac Myocytes Inhibited by Cyclosporin A

Terminal deoxy-nucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining of cardiac myocytes (mean % + SE) increased after 24 h with lipopolysaccharide (LPS) (10 ng/ml, n = 7) (A) or angiotensin II (Ang II) (100 nmol/l, n = 9) (B) compared with control (vehicle) (p < 0.05). In both cases, this was blocked by the cyclosporin A (0.5 µmol/l, 1 h before LPS or Ang II), while cyclosporin A alone had no effect (p < 0.05).