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Figure 1 Time Course and LPS Dose Dependence of Calcineurin Activity in Cardiac Myocytes

(A) Calcineurin activity in cardiac myocytes (mean ± SE, n = 4) increased with lipopolysaccharide (LPS) (10 ng/ml) compared with control (vehicle) after 1 to 24 h, with t 1/2 of 4.8 h (p < 0.05). (B) Lipopolysaccharide dose-calcineurin activity relationship (mean ± SE, n = 4). After 16 h incubation with LPS, calcineurin activity increased in cardiac myocytes with an EC₅₀ of 0.80 ng/ml LPS (p < 0.05).