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Figure 5 Hemorrhagic Events With rNAPc2

There was no difference between the rates of major plus minor hemorrhage among patients receiving recombinant nematode anticoagulant protein c2 (rNAPc2) versus placebo (3.7% vs. 2.5%, respectively), nor was there a trend across ascending doses (p = NS). All major and minor bleeding events were related to procedures; none were spontaneous. *3/4 major hemorrhages were CABG-related, 2 to 3 days after surgery. CABG = coronary artery bypass graft; Hgb = hemoglobin; ICH = intracranial hemorrhage; TIMI = Thrombolysis In Myocardial Infarction; UFH = unfractionated heparin.