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Figure 4 rNAPc2 Suppresses New Thrombin Generation

Prothrombin fragment 1.2 (F1.2), a marker of new thrombin generation, was reduced signficantly at 2 to 6 and 48 h with 7.5 µg/kg recombinant nematode anticoagulant protein c2 (rNAPc2) compared with placebo. Lower-dose rNAPc2 (1 to 5 µg/kg) blunted the increase in F1.2 seen at 48 h in the placebo group.