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Figure 1 Mechanisms of Vessel Wall Neovascularization in Atherosclerosis

Increased proangiogenic activity, which may be accompanied by reduced endogenous inhibition of angiogenesis, results in vasa vasorum proliferation and intimal neovascularization. FGF = fibroblast growth factors; HGF = hepatocyte growth factor; PDGF = platelet-derived growth factor; SMC = smooth muscle cell; VEGF= vascular endothelial growth factor. Copyrighted and used with permission of Mayo Foundation for Medical Education and Research.