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Figure 1 Principle of the MR-proADM Assay

A sketch of the adrenomedullin (ADM) precursor is shown, and amino acid positions in preproADM are denoted at which the precursor is proteolytically processed. Tracer- and solid phase–antibodies used in the sandwich immunoassay for the detection of midregional pro-adrenomedullin (MR-proADM) are indicated. PAMP = pro-adrenomedullin N-terminal 20 peptide; signal = signal peptide.