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Figure 2 Olmesartan Inhibits Up-Regulation of ACE in the Aortic Valve Induced by Dietary Cholesterol

Angiotensin-converting enzyme (ACE) immunostaining (black) in sections of aortic valve from control (A), hypercholesterolemic (B), and hypercholesterolemic olmesartan-treated (C) rabbits. Sections are counterstained with methyl green. Inset in B shows the aorta from the same section. Arrowheads indicate aortic side of the valve leaflet. (D) Quantitation of ACE-stained area corrected for total area. Ao = aorta. Bar = 200 µm.