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Figure 1 Hemodynamic Effects of BNP, SIL, or Both in Normal and Failing Hearts Assessed by Cardiac Pressure-Volume Loops

Representative left ventricular (LV) pressure-volume loops at baseline and after acute administration of B-type natriuretic peptide (BNP), sildenafil (SIL), or the combination of SIL + BNP. Top panels show pressure-volume loops for a non-failing dog (Normal) and the bottom panels for a dog after tachypacing-induced heart failure (Heart Failure).