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Figure 7 Influence of naloxone treatment on atherosclerotic lesion formation in apolipoprotein-E (apoE)-deficient mice (A) . The lipid-rich atherosclerotic lesions were identified with Oil-Red-O staining. Lesion area (%) was expressed as percentage of atherosclerotic area/total area of the aorta (B) . The apoE-deficient mice received an IP injection of phosphate-buffered saline (PBS) (n = 8), 10 mg/kg/day (n = 8), 20 mg/kg/day (n = 7), or 25 mg/kg/day (n = 5) naloxone for 10 weeks. The results are expressed as mean values ± SD. **p < 0.01; ***p < 0.005 compared with the control substance.