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Figure 2 Effect of naloxone treatment on oxidized low-density lipoprotein (oxLDL)-induced macrophage release of TNF- (A) , IL-6 (B) , and MCP-1 (C) . The THP-1 cell culture was pretreated for 1 h with the indicated concentrations of naloxone before stimulation with 10 µg/ml oxLDL. Supernatants were harvested at 24 h for the measurement of TNF-, IL-6, and MCP-1. The results are expressed as mean values ± SD of 3 experiments. *p < 0.05 compared with the oxLDL-treated cultures. Other abbreviations as in Figure 1 .