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Figure 1 Schematic representation of study design and numbers of subjects. Sample size was calculated based on earlier torcetrapib studies, with 25 subjects per group yielding 80% power to detect a 25% treatment difference in high-density lipoprotein cholesterol (HDL-C), assuming a common standard deviation of 30.5% and 2-sided t test with 5% type I error. LOCF = last observation carried forward (i.e., subjects with baseline and at least one post-baseline HDL-C measurement); R = randomization.