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Figure 3 Impact of therapy with isosorbide dinitrate and hydralazine (I/H) on outcomes in heart failure. (A) Effect on composite score in –344 genotype subsets. Treatment associated with marked improvement in the –344TT subset (n = 218, p = 0.01), but minimal effect in subjects with the –344 C allele (CC + TC, n = 136, p = NS). (B) Effect on change in quality-of-life scores from baseline to 6 months in –344 genotype subsets.