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Figure 2 Poincaré plots obtained from 30 left ventricular (LV) monophasic action potential duration (MAPD) (upper panels) and simultaneous RR intervals (lower panels) in a dog under the influence of low- (0.2 mg/kg, left panels) or high-dose (1.0 mg/kg, right panels) sertindole. At control (open arrows), comparable low LV short-term variability (2.3 and 2.5 ms, respectively) and LV MAPD are present. After administration of sertindole (closed arrows), the mean LV MAPD prolongs to similar levels, whereas LV short-term variability is only increased after the proarrhythmic high dose (2.6 and 5.2 ms, respectively). The RR short-term variability of the same beats remains unaltered although sertindole prolongs the mean RR interval (lower panels).