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Figure 4 Time course of changes in the parameter c from mechanical restitution curve (MRC) curve-fitting analysis (the decrease in LV+dP/dtmax with a 40% reduction in R-R interval from the fitted MRC model) for each of (A) metoprolol, (B) sotalol, and (C) verapamil. Asterisks indicate statistical significance compared with baseline (analysis of variance with repeated measures). (D) The increment in parameter c after drug treatment. Verapamil induces a significantly different response to metoprolol (analysis of variance). Abbreviations as in Figure 1.