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Figure 1 Combined receiver-operating characteristic (ROC) curves for amino-terminal pro-brain natriuretic peptide (NT-proBNP), galectin (gal)-3 and apelin for the diagnosis of heart failure in dyspneic patients. The ROC analysis for NT-proBNP showed an area under the curve (AUC) for NT-proBNP of 0.94 (p < 0.0001). The ROC analysis for gal-3 showed an AUC of 0.72 (p < 0.0001). The AUC for apelin for diagnosis of acute heart failure was 0.52 (p = 0.23).