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Figure 4 (A) Mean maximal ST-segment depression during exercise tolerance test (ETT) (mm) at baseline and on treatment (8 weeks) in the 33 women randomized to placebo (n = 17) or metformin (n = 16). (B) Median chest pain incidence before randomization and on treatment in the 33 women randomized to placebo (n = 17) or metformin (n = 16).