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Figure 3 (A) Change over 8 weeks in microvascular responses to acetylcholine (ACh) in metformin and placebo groups (p < 0.0001, 2-way repeated measures analysis of variance [ANOVA]). (B) Change over 8 weeks in microvascular responses to sodium nitroprusside (SNP) in metformin and placebo groups (p = 0.55, 2-way repeated measures ANOVA).