Click on image to view larger version.

Figure 2 (A) Baseline and on-treatment (8 weeks) microvascular responses to acetylcholine (ACh) in the 16 women randomized to metformin (p = 0.0003, 2-way repeated measures analysis of variance [ANOVA]). (B) Baseline and on-treatment (8 weeks) microvascular responses to ACh in the 17 women randomized to placebo (p = 0.50, 2-way repeated measures ANOVA). (C) Baseline and on-treatment (8 weeks) microvascular responses to sodium nitroprusside (SNP) in the 16 women randomized to metformin (p = 0.46, 2-way repeated measures ANOVA). (D) Baseline and on-treatment (8 weeks) microvascular responses to SNP in the 17 women randomized to placebo (p = 0.95, 2-way repeated measures ANOVA).