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Figure 4 Changes of vascular resistance in the extracorporeally perfused hind limb during a 10-min pump perfusion run. Under control conditions a triphasic response to pump perfusion is observed, consisting of a very short dilation, followed by 4 to 5 min of vasoconstriction and a longer-lasting vasodilation. Both parecoxib (parec) (A) and high-dose aspirin (B) significantly reinforced the vasoconstrictive response (p = 0.04 and p = 0.03, respectively). Pretreatment with a low dose of clopidogrel (clop) prevented the parecoxib-induced reinforcement of vasoconstriction (A). Low-dose aspirin failed to induce significant changes from control (B).