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Figure 1 Survival rate of different groups of mice: survival rate of mice undergoing cecal ligation and puncture without treatment (CLP) was compared with that of animals treated with 2, 10, and 100 mg/kg cyclosporine A (A) or N-methyl-4-isoleucine cyclosporine (NIM811) (B). Mice overexpressing B cell leukemia (Bcl)-2 had a survival rate of 80% (C). Sample size is 12 in each group. Survival studies were conducted twice. *p < 0.05, sham versus treatment or transgenic CLP mice; p < 0.05, CLP versus treatment or transgenic CLP mice, by Kaplan-Meier, log-rank.