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Figure 7 (A) Parasternal long- and short-axis views and tissue Doppler (TD) velocities at lateral and septal side of mitral annulus, from a 20-year-old subject carrying a known mutation for hypertrophic cardiomyopathy. Left ventricular hypertrophy is absent, but systolic (Sa) and early diastolic (Ea) velocities are reduced for age. (B) After 2 years, asymmetric septal hypertrophy developed and TD annular velocities remain reduced. AO = aorta; Aa = late diastolic velocity; LA = left atrium; LV = left ventricle; RV = right ventricle.