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Figure 5 Illustration of acute ST-segment changes recorded by implanted medical device, and correlation with necropsy findings. (A) Shows stable normal sinus rhythm without ST-segment shift at baseline 30 h after implanted medical device implant. (B) The animal receives an emergency ST-segment shift alert with pronounced ST-segment elevation 77 h after copper stent implantation in the left circumflex coronary artery. (C) The ST-segment resolves at 72 h after the alerting ST-segment elevation event. Angiography immediately after copper stent implants in the proximal left circumflex coronary artery (D) shows patency of left circumflex coronary artery (white arrows). The stents appear totally occluded at 25 days after copper stent implant by both angiography (white arrows, E) and histopathology (black arrows show inflammation around struts of copper stent) (F). The animal survived until sacrifice at 26 days after copper stent implant. Inflammation, with layers of occlusive thrombus with minor recanalization channels, is observed (F). (G) Shows a lateral and posterior transmural myocardial infarction (stained in blue) at 26 days after stent implant (black arrows).