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Figure 2 Components of the primary composite score by gender and treatment groups. The p values compare isosorbide dinitrate/hydralazine (I/H) with placebo in each group. Mortality was reduced by I/H in both men and women, with a slightly greater effect in women. First heart failure hospitalization was similarly reduced in both men and women, whereas change in quality of life (QoL) was improved in both genders without gender-by-treatment interaction.