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Figure 3 An example of a responder of cardiac resynchronization therapy (CRT) showing left ventricular (LV) reverse remodeling with reduction of LV end-systolic volume from 131 cc (A) to 78 cc (B) after CRT for 3 months. This patient had significant systolic asynchrony with asynchrony index (Ts-SD) of 41.0 ms at baseline. Tissue Doppler imaging showing great variations of time to peak systolic velocity (arrows) with delay in lateral wall at apical 4-chamber view (C), inferior wall at apical 2-chamber view (E), and posterior wall at apical long-axis (G) views. Such delay was abolished at the corresponding views after CRT for 3 months (D, F, and H). The asynchrony index was normalized to 21.4 ms.