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Figure 6 Histopathology of swine myocardial infarction at 8 weeks. (A) Irregular but clear interface between scar (S) and viable myocardium (VM). The infarct contains scattered, remodeled vessels (arrows) (100x, Masson’s trichrome). At high magnification (B, 400x, Masson’s trichrome), the scar comprises dense collagen that signifies a completely healed infarct. At the peri-infarction zone, the collagen interdigitates with viable myofibers. (C) Numerous uniformly distributed microvessels localized by brown reaction product between the non-stained myofibers in remote myocardium. In this transversely cut section, there is at least 1 vessel/myofiber (400x, biotinylated Baneiria simplicifolia isolectin B4). (D) Demonstrates the paucity of vessels in scarred myocardium. Brown reaction product localizes a haphazard array of sparse microvessels within the fibrous tissue (400x).