Click on image to view larger version.

Figure 2 Effect of the microvolt T-wave alternans (MTWA) hazard ratio on cost-effectiveness when comparing a risk stratification strategy with MTWA to medical therapy. As varying the MTWA hazard ratio changes the underlying baseline annual mortality rate, the effect of this variable on cost-effectiveness is performed as a two-way sensitivity analysis. Base-case estimates are for an annual mortality rate of 10.1% and a MTWA hazard ratio of 2.35. The incremental cost-effectiveness of a risk stratification strategy with MTWA compared to medical therapy becomes more favorable as the MTWA hazard ratio or the annual mortality rate increases. ICER = incremental cost-effectiveness ratio; QALY = quality-adjusted life-year.