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Figure 1 Changes in exercise variables, resting heart rate, and neurohormones for trained (open circles) and untrained patients (closed circles) at baseline, three, and nine months. *p < 0.05, **p < 0.01, ***p < 0.001 versus baseline (significant values assessed by Bonferroni post-hoc test performed on three groups); #p < 0.05, ##p < 0.01 versus third month. BNP = brain natriuretic peptide; b.p.m. = beats/min; NT-proBNP = amino-terminal pro-brain natriuretic peptide; VO2 = oxygen uptake.