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Figure 2 Chimerism of the transplanted female human heart. The localization of the Y-chromosome in the nucleus of a myocyte (A; alpha-sarcomeric actin, red; arrow), endothelial cell (B, arrow), and smooth muscle cells (B; -smooth muscle actin, red; arrowheads) is illustrated in the left ventricle of a female heart transplanted in a male recipient. Laminin defines the boundary of the cells (A, green). A red blood cell is present in the lumen of the coronary arteriole (B; glycophorin; A, yellow).