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Figure 13 Single detector polarization-sensitive ocular coherence tomography (PS-OCT) imaging. This image illustrates the principles behind single detector PS-OCT. In the trichrome stained section (A) of this in vitro coronary artery, the artery appears relatively homogeneous. In the picrosirius stained section (B), where brightness identifies organized collagen, it can be seen that the artery is heterogeneous by PS-OCT. The PS-OCT images (C and D), at two different polarization states, show different changes in backreflection intensity in different areas of the arteries. This is consistent with the heterogeneity of the picrosirius section. The largest OCT changes had a positive predictive power for collagen of 0.889, whereas the smallest change had a negative predictive power of 0.929.