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Figure 10 Qualitative proof of mismatch as the source of scattering. In the top image, saline is being circulated over a reflector. The top line is the inner layer of the tubing. The second line is the reflector. Saline is between them. In the middle image, blood is being circulated rather than saline through the system. The reflector is no longer seen. In the bottom image, blood has been removed, lysed, and reintroduced into the system. The signal off the reflector returned to values not significantly different than the control subject. Reprinted, with permission, from Circulation 2001;103:2000–4.